Brief Analysis of Evaluation Basis for Coating Quality of Tablet Coating Machine

        Brief Analysis of Evaluation Basis for Coating Quality of Tablet Coating Machine

        The tablet coating machine has convenient feeding and high efficiency; it is easy to clean and the coating pot can be disassembled by itself.

        The coating machine uses imported spray guns, which is easy to operate and easy to control. It can flexibly control the process requirements. The atomization effect is good and the liquid is sprayed evenly.

        The unique half-hole design and pot design of the machine help reduce the abrasion of the tablet core and the coating film, improve the yield, and therefore take into account the drying efficiency and the protection of the coating film. The machine can be equipped with 1-2 different pots according to the needs, in order to solve the confusion of many varieties, small quantities, and high raw material prices in the laboratory. The replaceable pot can better meet the needs of diverse customers.

        The evaluation of coating quality of tablet coating machine can be judged according to the following points:

        1. Appearance: The surface of the tablet should be uniform in color, smooth, no spots, no foreign matter, and remain unchanged within the specified validity period.

        2. Differences in tablet weight; sugar-coated tablets and film-coated tablets (including enteric-coated tablets) should be checked for weight differences in the core of the tablets before coating, and coating can be performed only after meeting the requirements; In addition, for tablets that have been specified for uniformity of content, it is not necessary to perform a check for differences in tablet weight.

        3. Disintegration: Ordinary oral coated tablets need to be checked for disintegration.

        4. Dissolution or release: Disintegration check sometimes does not correctly reflect the dissolution of the main drug and the absorption in the body, and the results of dissolution or release can indirectly reflect the absorption in the body. Therefore, the variety and number of dissolution tests are increasing, and there is a tendency to replace the disintegration check.

        5. Coated strength test (heat resistance test): 50 coated tablets were placed under a 250 W infrared lamp at 15 cm, heated for 4 h, and the changes in the one-sided surface were observed and recorded.

        6. Moisture and water resistance test: After the coated tablets are placed in a constant temperature and humidity device for a certain period of time, the weight gain of the tablet is used as an indicator to indicate the moisture and water resistance.